Which chromosomal mutation involves a segment of the chromosome being reversed end to end within the same chromosome?

Which chromosomal mutation involves a segment of the chromosome being reversed end to end within the same chromosome?

• A. Inversion Chromosomal Mutation
• B. Deletion Chromosomal Mutation
• C. Translocation Chromosomal Mutation
• D. Duplication Chromosomal Mutation

Answer: (A)

Inversion is a chromosomal mutation where a segment breaks in two places and reattaches in the opposite orientation, reversing the gene order within that region. Because this rearrangement happens within the same chromosome, it is an intra-chromosomal change. There are two common forms: paracentric inversions, which do not involve the centromere, and pericentric inversions, which do include the centromere. Inversions can be balanced, with no gain or loss of genetic material, but they can disrupt recombination during meiosis and potentially produce unbalanced gametes. This is different from deletion, which removes a segment; duplication, which creates an extra copy of a segment; and translocation, which moves a segment to a different chromosome or location.

Inversion is a chromosomal mutation where a segment breaks in two places and reattaches in the opposite orientation, reversing the gene order within that region. Because this rearrangement happens within the same chromosome, it is an intra-chromosomal change. There are two common forms: paracentric inversions, which do not involve the centromere, and pericentric inversions, which do include the centromere. Inversions can be balanced, with no gain or loss of genetic material, but they can disrupt recombination during meiosis and potentially produce unbalanced gametes. This is different from deletion, which removes a segment; duplication, which creates an extra copy of a segment; and translocation, which moves a segment to a different chromosome or location.